Cord blood cells (CBC) in the treatment of brain trauma and cerebral palsy
V.N. Smirnov
Department of Child Neurosurgery, Polenov Institute of Neurosurgery, Saint-Petersburg, Russia
Abstract:
This study was a pilot clinical trial (phase I-IIa) of safety and efficacy of CBC i ntravenous infusion in children with cerebral palsy and congenital hydrocephalus. 31 patient (2-10 years) had retarded psychomotor and physical development. After informed consents by parents, patients received one or two intravenous infusions of allogeneic, ABO/Rh-identical, RBC-depleated human CBC at average dose of 250х106 cells per infusion. Infusions were not accompanied by any complications. Positive dynamics was registered in 17 patients (54,8%) after 2 infusions. All patients of this group had psychoemotional improvement and elevation of attention concentration. In 7 patients (22,6%) weakening of paresis by 1-2 points was seen. In 1 patient with congenital amavrosis the improvement of visual function and small motorics was observed. In 7 patients (22,6%) where cerebral palsy or hydrocephalus was combined with epilepsy, diminution of frequency of seasures by 28% was recordered. Thus, in patients with neurological deficit due to congenital hydrocephaly and spastic forms of cerebral palsy the addition of CBC infusion to standard therapy improve the results of standard medical treatment.
